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KMID : 0604520060320010053
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 1 p.53 ~ p.58
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Studies on the Anti-acne Effect of Agrimonia pilosa Ledeb
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Yoon Chang-Soon
Kim Hyun-Joo
Lim Hye-Won
Kim Bo-Hyun
Kim Hak-Soo
Choi Shin-Wook
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Abstract
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Agrimonia pilosa Ledeb. is a perennial plant, which naturally habitats in whole area of Korea, and where it is popularly used for the traditional remedies. In the present study, A. pilosa Ledeb. extract was prepared to determine the anti-acne effects and application possibility as a cosmetic resource. A pilosa Ledeb. was extracted with methanol and its anti-acne effect against Propionibacterium acnes was investigated via minimum inhibitory concentration (MIC) and paper disk diffusion method. The MIC of A. pilosa Ledeb. extract and triclosan was 0.05 mg/mL and 0.04 mg/mL, respectively. This implies that A. pilosa Ledeb. extract nay be an efficient anti-acne ingredient for cosmetics, considering that it is a crude extract. The paper disk diffusion assay showed that its anti-acne effect was similar to that of triclosan. Furthermore, A. pilosa Ledeb. extract effectively inhibited the growth of several aerobic microorganisms including Staphylococcus aureus. Finally, we examine the stability of the extract to temperature and pH. The extract was very stable to high temperatures (70{sim}121^{circ}C) and to pH (pH 2{sim}11), suggesting its utilization for cosmetics.
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KEYWORD
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Agrimonia pilosa Ledeb., anti-acne activity, MIC, Staphylococcus aureus, stability
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